Tool Introduction
The Endogenous Creatinine Clearance Rate (CCR) Calculator is an online tool specifically designed to assess glomerular filtration function. It quickly and accurately estimates the endogenous creatinine clearance rate based on the user's gender, weight, age, and serum creatinine values, and provides kidney function staging and health status recommendations according to international general standards. CCR is an important indicator in clinical practice for judging kidney health, monitoring kidney function progression, and adjusting drug dosages. This tool aims to provide users with a convenient preliminary assessment of kidney function to help them understand their kidney health status.
How to Use
- Select Gender: In the “Gender” option, select “Male” or “Female” according to your actual situation.
- Enter Weight: In the “Weight” input box, fill in your weight, in “kg”. Please ensure the input value is between 1 and 300 kg.
- Enter Age: In the “Age” input box, fill in your age in “years old”. Please ensure the input value is between 1 and 120 years old.
- Enter Serum Creatinine: In the “Serum Creatinine” input box, fill in your serum creatinine test value, in “umol/L”. Please ensure the input value is a positive integer.
- Click Calculate: After completing all inputs, click the calculate button (in actual operation, it may be automatic calculation or require clicking a specific button).
- View Results: The tool will immediately display the calculated “Endogenous Creatinine Clearance Rate CCR” value, “Kidney Status” assessment (e.g., Normal, Slight Impairment, etc., with status indicator colors), and “Normal Range” for your reference.
Frequently Asked Questions
- Q: What is the clinical significance of Endogenous Creatinine Clearance Rate (CCR)?
A: CCR is an important indicator for assessing glomerular filtration function. It reflects the kidney's ability to clear creatinine from plasma per minute, thereby indirectly reflecting the kidney's function in excreting metabolic waste. It has important guiding significance for the early detection of kidney diseases, monitoring disease progression, and adjusting drug dosages.
- Q: How to interpret the classification results of “Kidney Status”?
A: Based on the calculated CCR value, this tool classifies kidney function status into different levels such as “Normal”, “Slight Impairment”, “Moderate Impairment”, “Severe Impairment”, or “Early/Late Renal Insufficiency” and marks them with different colors. These classifications help users intuitively understand the degree of kidney health and correspond to different clinical intervention recommendations. For example, if it shows “Normal”, it means kidney function is good; if it shows “Moderate Impairment”, it suggests that kidney function has declined to some extent, and further medical examination is recommended.
- Q: Is serum creatinine value affected by diet or exercise?
A: Yes, serum creatinine levels can be affected by various factors. For example, strenuous exercise and high intake of meat (especially red meat) may temporarily increase serum creatinine levels. Therefore, to obtain more accurate assessment results, it is recommended to avoid strenuous exercise and high-protein diet before physical examination, and to perform serum creatinine testing when the body is in a stable state. Generally, strict fasting is not required.
Important Notes
- Data Accuracy: Please ensure that the gender, weight, age, and serum creatinine data you enter are true and valid; incorrect input will lead to inaccurate calculation results.
- Unit Consistency: The input unit for serum creatinine must be “umol/L”. If your test report uses other units (e.g., mg/dL), please be sure to convert the units first (1 mg/dL ≈ 88.4 umol/L) before entering.
- Results for Reference Only: The endogenous creatinine clearance rate and kidney status assessment provided by this tool are estimated values, intended for preliminary reference. It cannot replace professional medical diagnosis and doctor's advice; any abnormal kidney function should be promptly consulted with a professional doctor.
- Influencing Factors: The calculation and actual value of CCR can be affected by various factors such as individual muscle mass, medication use, acute and chronic diseases, dehydration status, etc. Therefore, the interpretation of the results needs to be combined with individual specific circumstances.
CCR Calculation Formula
This tool primarily uses the modified Cockcroft-Gault formula to estimate endogenous creatinine clearance rate. This formula considers factors such as gender, age, weight, and serum creatinine, and is one of the commonly used calculation methods in clinical practice. The specific calculation formulas are as follows:
- Male: Ccr (mL/min) = (140 - Age) × Weight (kg) × 1.23 / Serum Creatinine (μmol/L)
- Female: Ccr (mL/min) = (140 - Age) × Weight (kg) × 1.04 / Serum Creatinine (μmol/L)
Where age is in years old, weight is in kg, and serum creatinine is in μmol/L.
Kidney Function Staging Criteria
The assessment of kidney function status by this tool primarily refers to the internationally accepted Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines for kidney function staging based on eGFR (or CCR):
- Normal: CCR ≥ 90 mL/min
- Slight Impairment (Chronic Kidney Disease Stages 1-2): CCR 60-89 mL/min
- Moderate Impairment (Chronic Kidney Disease Stage 3): CCR 30-59 mL/min
- Severe Impairment (Chronic Kidney Disease Stage 4): CCR 15-29 mL/min
- Late Renal Insufficiency (Chronic Kidney Disease Stage 5, Kidney Failure): CCR < 15 mL/min
These stages help clinicians and patients understand the degree of kidney damage and take appropriate management and treatment measures.
