Tool Introduction
The Endogenous Creatinine Clearance Rate (CCR) Calculator is an online tool specifically designed to assess glomerular filtration function. It quickly and accurately estimates the endogenous creatinine clearance rate based on the user's gender, weight, age, and serum creatinine value, and provides kidney function staging and health status suggestions according to international general standards. CCR is an important indicator in clinical practice for judging kidney health status, monitoring kidney function progression, and adjusting drug dosages. This tool aims to provide users with a convenient preliminary assessment of kidney function, helping them understand their kidney health status.
How to Use
- Select Gender: In the "Gender" option, select "Male" or "Female" according to your actual situation.
- Enter Weight: In the "Weight" input box, fill in your weight, in "kilograms". Please ensure the input value is between 1 and 300 kg.
- Enter Age: In the "Age" input box, fill in your age in years. Please ensure the input value is between 1 and 120 years old.
- Enter Serum Creatinine: In the "Serum Creatinine" input box, fill in your serum creatinine test value, in "umol/L". Please ensure the input value is a positive integer.
- Click Calculate: After completing all inputs, click the calculate button (in actual operation, it may be automatic calculation or require clicking a specific button).
- View Results: The tool will immediately display the calculated "Endogenous Creatinine Clearance Rate CCR" value, "Kidney State" assessment (such as normal, slight damage, etc., with status indicator colors), and "Standard Range" for your reference.
Frequently Asked Questions
- Q: What is the clinical significance of endogenous creatinine clearance rate CCR?
A: CCR is an important indicator for evaluating glomerular filtration function. It reflects the kidney's ability to clear creatinine from plasma per minute, thereby indirectly reflecting the kidney's function of excreting metabolic waste. It has important guiding significance for the early detection of kidney diseases, monitoring of disease progression, and adjustment of drug dosages.
- Q: How to interpret the classification results of "Kidney State"?
A: This tool classifies kidney function status into different levels such as "Normal", "Slight Damage", "Moderate Damage", "Severe Damage", or "Early/Late Renal Insufficiency" based on the calculated CCR value, and uses different colors to identify them. These classifications help users intuitively understand the health status of their kidneys and correspond to different clinical intervention recommendations. For example, if it shows "Normal", it means good kidney function; if it shows "Moderate Damage", it indicates that kidney function has declined to a certain extent, and further examination is recommended.
- Q: Is serum creatinine value affected by diet or exercise?
A: Yes, serum creatinine levels can be affected by various factors. For example, strenuous exercise and a large intake of meat (especially red meat) may increase serum creatinine levels in a short period. Therefore, to obtain more accurate assessment results, it is recommended to avoid strenuous exercise and high-protein diet before the physical examination, and to perform serum creatinine testing when the body is in a stable state. Generally, strict fasting is not required.
Precautions
- Data Accuracy: Please ensure that the gender, weight, age, and serum creatinine data you enter are true and valid. Incorrect input will lead to inaccurate calculation results.
- Unit Consistency: The input unit for serum creatinine must be "umol/L". If your test report uses other units (such as mg/dL), please be sure to convert the units first (1 mg/dL ≈ 88.4 umol/L) before entering.
- Results for Reference Only: The endogenous creatinine clearance rate and its kidney status assessment provided by this tool are estimated values and are intended for preliminary reference only. It cannot replace professional medical diagnosis and doctor's advice. Any kidney function abnormality should be promptly consulted with a professional doctor.
- Influencing Factors: The calculation and actual value of CCR are affected by various factors such as individual muscle mass, drug use, acute and chronic diseases, and dehydration status. Therefore, the interpretation of the results needs to be combined with individual specific circumstances.
CCR Calculation Formula
This tool mainly uses the modified Cockcroft-Gault formula to estimate the endogenous creatinine clearance rate. This formula considers factors such as gender, age, weight, and serum creatinine, and is one of the commonly used calculation methods in clinical practice. The specific calculation formula is as follows:
- Males: Ccr (mL/min) = (140 - Age) × Weight (kg) × 1.23 / Serum Creatinine (μmol/L)
- Females: Ccr (mL/min) = (140 - Age) × Weight (kg) × 1.04 / Serum Creatinine (μmol/L)
Where age is in years, weight is in kilograms, and serum creatinine is in μmol/L.
Kidney Function Staging Standards
The assessment of kidney function status by this tool mainly refers to the internationally accepted Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines for kidney function staging based on eGFR (or CCR):
- Normal: CCR ≥ 90 mL/min
- Slight Damage (Chronic Kidney Disease Stages 1-2): CCR 60-89 mL/min
- Moderate Damage (Chronic Kidney Disease Stage 3): CCR 30-59 mL/min
- Severe Damage (Chronic Kidney Disease Stage 4): CCR 15-29 mL/min
- Late Renal Insufficiency (Chronic Kidney Disease Stage 5, Renal Failure): CCR < 15 mL/min
These stages help clinicians and patients understand the degree of kidney damage and take appropriate management and treatment measures.
